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Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 323-328 doi: 10.1007/s11684-010-0026-5

Abstract: This study explored the effects of nuclear factor-kappa B (NF-κB) inhibitor Bay 11-7082 on Fas/FasL system

Keywords: nuclear factor-kappa B     Fas/FasL system     HL-60     Bay 11-7082    

Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis

Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 475-479 doi: 10.1007/s11684-009-0086-6

Abstract: The expression of signal transducer and activator of transcription 6 (STAT6) and nuclear factorB (NF-κB) in the colonic mucosa of patients with ulcerative colitis (UC) was examined.polymerase chain reaction and immunohistochemistry were used to detect the expression of STAT6 and NF-κBThe results showed that the expression levels of STAT6 and NFκB p65 in the colonic mucosa of patientsThese data suggest that STAT6 and NFκB p65 perhaps play an important role in the pathogenesis of

Keywords: ulcerative colitis     signal transducer and activator of transcription 6 (STAT6)     nuclear factor    Bp65 (NF-κ     B p65)    

Tramadol reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic factorand tropomyosin-related kinase B in rat hippocampus

Chun Yang, Xiaomin Li, Nan Wang, Shixia Xu, Jianjun Yang, Zhiqiang Zhou

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 411-415 doi: 10.1007/s11684-012-0226-2

Abstract: Brain-derived neurotrophic factor (BDNF) is an important biomarker for mood disorders and tropomyosin-relatedkinase B (TrkB) is a high affinity catalytic receptor for BDNF.

Keywords: tramadol     ketamine     antidepressant     brain-derived neurotrophic factor     tropomyosin-related kinase B    

Inhibition of the nuclear export of p65 and IQCG in leukemogenesis by NUP98-IQCG

Mengmeng Pan,Qiyao Zhang,Ping Liu,Jinyan Huang,Yueying Wang,Saijuan Chen

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 410-419 doi: 10.1007/s11684-016-0489-0

Abstract: association of NUP98-IQCG with CRM1, and found that NUP98-IQCG expression inhibits the CRM1-mediated nuclearexport of p65 and enhances the transcriptional activity of nuclear factor-κB.Therefore, the inhibition of nuclear exports of p65 and IQCG might contribute to the leukemogenesis of

Keywords: NUP98-IQCG     nuclear export     NF-κB     CRM1    

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K

LI Yanhua, BI Zhigang

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 79-86 doi: 10.1007/s11684-007-0016-4

Abstract: The aim of this research was to explore the effects and signaling pathway of ultraviolet-B (UVB) irradiationon the expression of hypoxia-inducible factor 1α (HIF-1α) and transferrin receptor (TfR).Expressions of epidermal growth factor receptor (EGFR), phosphor-EGF-R and TfR after UVB irradiation

Effect of compound Sophorae Flavescentis Jiechangrong capsule on expression of NF-κB p65 and STAT6

Heng FAN MD, Jia ZHAO MM, Lin SHEN BM, Qing TANG MD, Zhexin SHOU MM, Li LIANG BM, Yi LIAO BM, Xiaoyan CHEN BM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 480-484 doi: 10.1007/s11684-009-0083-9

Abstract: The effects of compound Sophorae Flavescentis Jiechangrong capsule (CSFJC) on the expression of nuclearfactorB p65 (NF-κB p65) and signal transducer and activator of transcription 6 (STAT6) inAfter the treatment, the expression of NF-κB p65 and STAT6 in the two groups was decreased, andthe decrease of NF-κB p65 and STAT6 expression in TCM group was more significant than in WM groupIt was concluded that CSFJC can inhibit the activation and expression of NF-κB p65 and STAT6 in

Keywords: colitis     ulcerative     compound Sophorae Flavescentis Jiechangrong capsule     nuclear factor    B p65 (NF-κ     B p65)     signal transducer and activator of transcription 6 (STAT6)    

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 106-111 doi: 10.1007/s11684-010-0004-y

Abstract: Hepatitis B virus X protein (HBx), a 17-kd protein encoded by X gene of hepatitis B virus (HBV), hasprotein kinases (ERKs) pathway of HBx on glomerular mesangial cell (GMC) proliferation and tumor necrosis factor

Keywords: hepatitis B virus     X gene     glomerular mesangial cell line     extracellular regulated protein kinases     tumornecrosis factor   

Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain: involvement of histone deacetylase inhibition

Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 79-90 doi: 10.1007/s11684-020-0783-8

Abstract: ASIV restored acetylation of histone H3 and the p65 subunit of nuclear factorB in the ischemic brainSimultaneously, ASIV prevented p65 nuclear translocation.The effects of ASIV on reducing CCL2 production, restoring acetylated p65 levels and preventing p65 nuclear

Keywords: astragaloside IV     brain ischemia     natural killer cells     histone deacetylase     nuclear factorB    

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 90-99 doi: 10.1007/s11684-015-0390-2

Abstract:

Gene therapy provides a potential cure for hemophilia B, and significant progress has been achievedtrials involving the use of a self-complementary adeno-associated virus serotype 8-human codon-optimized factorvectors and hFIX expression cassette may positively contribute to the ultimate success of hemophilia BAAV vector may potentially contribute to the creation of an efficacious gene therapy of hemophilia B.

Keywords: factor IX     hemophilia B     liver-specific regulatory elements     hydrodynamic gene transfer    

Materials Design on the Origin of Gap States in a High-κ/GaAs Interface Article

Weichao Wang,Cheng Gong,Ka Xiong,Santosh K.C.,Robert M. Wallace,Kyeongjae Cho

Engineering 2015, Volume 1, Issue 3,   Pages 372-377 doi: 10.15302/J-ENG-2015052

Abstract: However, upon interfacing with high dielectric constant (high-κ) dielectrics, the electron mobility

Keywords: high-mobility device     high-&kappa     /III-V interface     interfacial gap states     first-principle calculations    

Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse largeB-cell lymphoma

Yiwen Cao, Zhenhua Liu, Wen Wu, Ying Qian, Qin Shi, Rong Shen, Binshen Ouyang, Pengpeng Xu, Shu Cheng, Jin Ye, Yiming Lu, Chaofu Wang, Chengde Yang, Li Wang, Weili Zhao

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 94-103 doi: 10.1007/s11684-019-0680-1

Abstract: prognostic value of pretreatment immunologic markers in newly diagnosed patients with diffuse large B-cellMeanwhile, advanced Ann Arbor stage was an independent adverse prognostic factor for PFS (P=0.001

Keywords: immunologic marker     diffuse large B-cell lymphoma     prognosis    

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Engineering 2024, Volume 32, Issue 1,   Pages 58-69 doi: 10.1016/j.eng.2023.09.019

Abstract:

Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkhead

Keywords: Clustered regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9)     Epigenetics     Hepatocyte nuclearfactor 1 alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkhead box protein A2 (FOXA2)    

A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 275-289 doi: 10.1007/s11684-022-0945-y

Abstract: nasopharyngeal carcinoma (NPC) and explored the anti-tumor effects of the novel pan-HER inhibitor HM781-36B,HM781-36B inhibited NPC in vitro and in vivo.HM781-36B exerted synergistic effects with cisplatin on inhibiting proliferation and promoting apoptosisIn NPC xenograft models in nude mice, HM781-36B and cisplatin synergistically inhibited tumor growth.The pan-HER inhibitor HM781-36B alone or in combination with cisplatin represents promising therapeutic

Keywords: epidermal growth factor receptor     ErbB receptors     HM781-36B     nasopharyngeal carcinoma     molecular targeted    

Special issue: innovative nuclear energy technology

Frontiers in Energy 2021, Volume 15, Issue 4,   Pages 791-792 doi: 10.1007/s11708-021-0794-4

An old issue and a new challenge for nuclear reactor safety

F. D’AURIA

Frontiers in Energy 2021, Volume 15, Issue 4,   Pages 854-859 doi: 10.1007/s11708-021-0729-0

Abstract: Nuclear reactor safety (NRS) and the branch accident analysis (AA) constitute proven technologies: theseamong the other things, long lasting research and operational experience in the area of water cooled nuclearWeaknesses became evident, noticeably in relation to nuclear fuel under high burn-up.

Keywords: large break loss of coolant accident (LBLOCA)     nuclear reactor safety (NRS)     licensing perspectives     basisfor design of water cooled nuclear reactors (WCNR)    

Title Author Date Type Operation

Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Journal Article

Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis

Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,

Journal Article

Tramadol reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic factorand tropomyosin-related kinase B in rat hippocampus

Chun Yang, Xiaomin Li, Nan Wang, Shixia Xu, Jianjun Yang, Zhiqiang Zhou

Journal Article

Inhibition of the nuclear export of p65 and IQCG in leukemogenesis by NUP98-IQCG

Mengmeng Pan,Qiyao Zhang,Ping Liu,Jinyan Huang,Yueying Wang,Saijuan Chen

Journal Article

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K

LI Yanhua, BI Zhigang

Journal Article

Effect of compound Sophorae Flavescentis Jiechangrong capsule on expression of NF-κB p65 and STAT6

Heng FAN MD, Jia ZHAO MM, Lin SHEN BM, Qing TANG MD, Zhexin SHOU MM, Li LIANG BM, Yi LIAO BM, Xiaoyan CHEN BM,

Journal Article

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Journal Article

Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain: involvement of histone deacetylase inhibition

Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang

Journal Article

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Journal Article

Materials Design on the Origin of Gap States in a High-κ/GaAs Interface

Weichao Wang,Cheng Gong,Ka Xiong,Santosh K.C.,Robert M. Wallace,Kyeongjae Cho

Journal Article

Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse largeB-cell lymphoma

Yiwen Cao, Zhenhua Liu, Wen Wu, Ying Qian, Qin Shi, Rong Shen, Binshen Ouyang, Pengpeng Xu, Shu Cheng, Jin Ye, Yiming Lu, Chaofu Wang, Chengde Yang, Li Wang, Weili Zhao

Journal Article

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Journal Article

A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal carcinoma

Journal Article

Special issue: innovative nuclear energy technology

Journal Article

An old issue and a new challenge for nuclear reactor safety

F. D’AURIA

Journal Article